PET study of brain acetylcholinesterase in cerebellar degenerative disorders
Identifieur interne : 002719 ( Main/Exploration ); précédent : 002718; suivant : 002720PET study of brain acetylcholinesterase in cerebellar degenerative disorders
Auteurs : Shigeki Hirano [Japon] ; Hitoshi Shinotoh [Japon] ; Kimihito Arai [Japon] ; Akiyo Aotsuka [Japon] ; Fumihiko Yasuno [Japon] ; Noriko Tanaka [Japon] ; Tsuneyoshi Ota [Japon] ; Koichi Sato [Japon] ; Kiyoshi Fukushi [Japon] ; Shuji Tanada [Japon] ; Takamichi Hattori [Japon] ; Toshiaki Irie [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acetylcholine, Acetylcholinesterase, Acetylcholinesterase (metabolism), Adult, Aged, Brain (radionuclide imaging), Carbon Radioisotopes (diagnostic use), Cerebellar Cortex (radionuclide imaging), Cerebellum, Cerebral Cortex (radionuclide imaging), Emission tomography, Encephalon, Female, Humans, Image Processing, Computer-Assisted, Machado-Joseph Disease (radionuclide imaging), Magnetic Resonance Imaging, Male, Middle Aged, Multiple System Atrophy (radionuclide imaging), Multiple system atrophy, Nervous system diseases, Neurologic Examination, Piperidines (diagnostic use), Positron emission tomography, Positron-Emission Tomography, Propionates (diagnostic use), Spinocerebellar Ataxias (radionuclide imaging), Spinocerebellar Degenerations (radionuclide imaging), Spinocerebellar ataxia, Thalamus, Thalamus (radionuclide imaging), acetylcholine, multiple system atrophy, positron emission tomography, spinocerebellar ataxia, thalamus.
- MESH :
- chemical , diagnostic use : Carbon Radioisotopes, Piperidines, Propionates.
- chemical , metabolism : Acetylcholinesterase.
- radionuclide imaging : Brain, Cerebellar Cortex, Cerebral Cortex, Machado-Joseph Disease, Multiple System Atrophy, Spinocerebellar Ataxias, Spinocerebellar Degenerations, Thalamus.
- Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Positron-Emission Tomography.
Abstract
To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA‐C), 7 patients with spinocerebellar ataxia type‐3 (SCA‐3), 3 patients with SCA‐6, and 13 healthy age‐matched volunteers participated in this study. Brain AChE activity was measured by [11C] N‐methylpiperidin‐4‐yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (−27%) and the posterior lobe of cerebellar cortex (−36%) in patients with MSA‐C and in the thalamus (−23%) in patients with SCA‐3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA‐3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA‐3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22056
Affiliations:
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wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Asahi Hospital for Neurological Diseases, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Hospital Organization Chiba‐East Hospital, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba Aoba Municipal Hospital, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yasuno, Fumihiko" sort="Yasuno, Fumihiko" uniqKey="Yasuno F" first="Fumihiko" last="Yasuno">Fumihiko Yasuno</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Psychiatry, University of Tsukuba Hospital, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation><affiliation wicri:level="3"><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName><wicri:orgArea>Department of Neurosurgery, Tokyo Women's Medical University, Medical Center East</wicri:orgArea></affiliation></author><author><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation><affiliation wicri:level="3"><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName><wicri:orgArea>Department of Psychiatry, Juntendo University School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Psychiatry, Teikyo University School of Medicine, Ichihara Hospital, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Fukushi, Kiyoshi" sort="Fukushi, Kiyoshi" uniqKey="Fukushi K" first="Kiyoshi" last="Fukushi">Kiyoshi Fukushi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Tanada, Shuji" sort="Tanada, Shuji" uniqKey="Tanada S" first="Shuji" last="Tanada">Shuji Tanada</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University Graduate School of Medicine, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Irie, Toshiaki" sort="Irie, Toshiaki" uniqKey="Irie T" first="Toshiaki" last="Irie">Toshiaki Irie</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-06-15">2008-06-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1160">1160</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">16B3D727105BC3F28F6FBF8B40F670E455699ECC</idno><idno type="DOI">10.1002/mds.22056</idno><idno type="ArticleID">MDS22056</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine</term><term>Acetylcholinesterase</term><term>Acetylcholinesterase (metabolism)</term><term>Adult</term><term>Aged</term><term>Brain (radionuclide imaging)</term><term>Carbon Radioisotopes (diagnostic use)</term><term>Cerebellar Cortex (radionuclide imaging)</term><term>Cerebellum</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Emission tomography</term><term>Encephalon</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Machado-Joseph Disease (radionuclide imaging)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Piperidines (diagnostic use)</term><term>Positron emission tomography</term><term>Positron-Emission Tomography</term><term>Propionates (diagnostic use)</term><term>Spinocerebellar Ataxias (radionuclide imaging)</term><term>Spinocerebellar Degenerations (radionuclide imaging)</term><term>Spinocerebellar ataxia</term><term>Thalamus</term><term>Thalamus (radionuclide imaging)</term><term>acetylcholine</term><term>multiple system atrophy</term><term>positron emission tomography</term><term>spinocerebellar ataxia</term><term>thalamus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Carbon Radioisotopes</term><term>Piperidines</term><term>Propionates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Cerebellar Cortex</term><term>Cerebral Cortex</term><term>Machado-Joseph Disease</term><term>Multiple System Atrophy</term><term>Spinocerebellar Ataxias</term><term>Spinocerebellar Degenerations</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acetylcholinesterase</term><term>Acétylcholine</term><term>Ataxie spinocérébelleuse</term><term>Atrophie multisystématisée</term><term>Cervelet</term><term>Encéphale</term><term>Pathologie du système nerveux</term><term>Thalamus</term><term>Tomographie par émission de positons</term><term>Tomoscintigraphie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To elucidate characteristic changes of brain acetylcholinesterase (AChE) in cerebellar degenerative disorders. Eight patients with the cerebellar variant of multiple system atrophy (MSA‐C), 7 patients with spinocerebellar ataxia type‐3 (SCA‐3), 3 patients with SCA‐6, and 13 healthy age‐matched volunteers participated in this study. Brain AChE activity was measured by [11C] N‐methylpiperidin‐4‐yl propionate PET in all subjects. Brain AChE activities were significantly decreased in the thalamus (−27%) and the posterior lobe of cerebellar cortex (−36%) in patients with MSA‐C and in the thalamus (−23%) in patients with SCA‐3 compared with healthy controls (P < 0.01). Thalamic AChE activities of SCA‐3 patients were negatively correlated with the unified Parkinson's disease rating scale motor subscore (P < 0.001). AChE activities were not significantly altered in the cerebral cortex in any disease group. Reduction of AChE activities in the thalamus and cerebellum in MSA and in the thalamus in SCA‐3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Hirano, Shigeki" sort="Hirano, Shigeki" uniqKey="Hirano S" first="Shigeki" last="Hirano">Shigeki Hirano</name></noRegion><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name><name sortKey="Aotsuka, Akiyo" sort="Aotsuka, Akiyo" uniqKey="Aotsuka A" first="Akiyo" last="Aotsuka">Akiyo Aotsuka</name><name sortKey="Arai, Kimihito" sort="Arai, Kimihito" uniqKey="Arai K" first="Kimihito" last="Arai">Kimihito Arai</name><name sortKey="Fukushi, Kiyoshi" sort="Fukushi, Kiyoshi" uniqKey="Fukushi K" first="Kiyoshi" last="Fukushi">Kiyoshi Fukushi</name><name sortKey="Hattori, Takamichi" sort="Hattori, Takamichi" uniqKey="Hattori T" first="Takamichi" last="Hattori">Takamichi Hattori</name><name sortKey="Hirano, Shigeki" sort="Hirano, Shigeki" uniqKey="Hirano S" first="Shigeki" last="Hirano">Shigeki Hirano</name><name sortKey="Irie, Toshiaki" sort="Irie, Toshiaki" uniqKey="Irie T" first="Toshiaki" last="Irie">Toshiaki Irie</name><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name><name sortKey="Ota, Tsuneyoshi" sort="Ota, Tsuneyoshi" uniqKey="Ota T" first="Tsuneyoshi" last="Ota">Tsuneyoshi Ota</name><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name><name sortKey="Sato, Koichi" sort="Sato, Koichi" uniqKey="Sato K" first="Koichi" last="Sato">Koichi Sato</name><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name><name sortKey="Shinotoh, Hitoshi" sort="Shinotoh, Hitoshi" uniqKey="Shinotoh H" first="Hitoshi" last="Shinotoh">Hitoshi Shinotoh</name><name sortKey="Tanada, Shuji" sort="Tanada, Shuji" uniqKey="Tanada S" first="Shuji" last="Tanada">Shuji Tanada</name><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name><name sortKey="Tanaka, Noriko" sort="Tanaka, Noriko" uniqKey="Tanaka N" first="Noriko" last="Tanaka">Noriko Tanaka</name><name sortKey="Yasuno, Fumihiko" sort="Yasuno, Fumihiko" uniqKey="Yasuno F" first="Fumihiko" last="Yasuno">Fumihiko Yasuno</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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